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Invitrogen

CD3/CD20 (Glofitamab Biosimilar) Recombinant Humanized mouse Monoclonal Antibody

查看其他7个CD3/CD20抗体

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产品信息

MA5-42274

应用
建议稀释比
已发表文章

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Artificial Control / IgG1, kappa/IgG1, lambda

Expression System

CHO cells

分类

Recombinant Monoclonal

类型

Antibody

抗原

Human CD3E/MS4A1

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A/G

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2911417

产品详细信息

Endotoxin level < 0.01EU/µg by LAL method

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

靶标信息

The CD3 antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by normal and neoplastic T-lymphocytes. It stains human T-lymphocytes in both cortex and medulla of the thymus and in peripheral lymphoid tissues. CD20 is a non-Ig differentiation antigen of B-lymphocytes and the expression of CD20 is restricted to normal and neoplastic B-lymphocytes, being absent from all other leukocytes and tissues. The CD3-CD20 cocktail reveals lymphoid architecture in neoplastic situations.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: B-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; B-lymphocyte surface antigen B1; Bp35; CD20; CD20 antigen; CD20 receptor; CD3 antigen, delta subunit; CD3 delta; CD3-epsilon; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; OKT3, delta chain; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; unnamed protein product

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基因别名: B1; Bp35; CD20; CD3-DELTA; CD3-GAMMA; CD3D; CD3DELTA; CD3E; CD3epsilon; CD3G; CD3GAMMA; CVID5; FMC7; IMD17; IMD18; IMD19; LEU-16; MS4A1; S7; T3D; T3E; T3G; TCRE

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UniProt ID: (Human) P04234, (Human) P07766, (Human) P09693, (Human) P11836

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Entrez Gene ID: (Human) 915, (Human) 916, (Human) 917, (Human) 931

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功能
transmembrane signaling receptor activity protein binding identical protein binding SH3 domain binding protein kinase binding receptor signaling complex scaffold activity T cell receptor binding epidermal growth factor receptor binding immunoglobulin binding MHC class II protein complex binding
参与通路
adaptive immune response immune system process cell surface receptor signaling pathway positive thymic T cell selection alpha-beta T cell activation T cell receptor signaling pathway establishment or maintenance of cell polarity protein transport T cell activation gamma-delta T cell activation protein-containing complex assembly regulation of lymphocyte apoptotic process store-operated calcium entry humoral immune response response to bacterium B cell differentiation B cell proliferation B cell activation B cell receptor signaling pathway protein tetramerization calcium ion import into cytosol positive regulation of calcium ion import across plasma membrane positive regulation of cell-matrix adhesion positive regulation of T cell anergy T cell anergy transmembrane receptor protein tyrosine kinase signaling pathway signal complex assembly G-protein coupled receptor signaling pathway smoothened signaling pathway regulation of signal transduction positive regulation of gene expression negative regulation of gene expression dendrite development calcium-mediated signaling cerebellum development T cell costimulation positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of cell-cell adhesion mediated by integrin CD4-positive, alpha-beta T cell proliferation T cell proliferation positive regulation of T cell proliferation regulation of apoptotic process positive regulation of MAPK cascade negative thymic T cell selection negative regulation of smoothened signaling pathway lymphocyte activation positive regulation of calcium-mediated signaling positive regulation of T cell activation apoptotic signaling pathway positive regulation of CD4-positive, alpha-beta T cell proliferation
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