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Invitrogen

CD32a/CD32b/CD32c Recombinant Rabbit Monoclonal Antibody (K01_4P79)

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产品信息

MA567576

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_4P79

抗原

A synthesized peptide derived from human CD32A + CD32B + CD32C.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 50% glycerol, 150mM NaCl, 0.05% BSA

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

CD32 denotes Fc gamma receptor II family members that bind the Fc portion of IgG and modulate immune cell activation. CD32a is encoded by FCGR2A and is an activating receptor with an immunoreceptor tyrosine based activation motif that signals through Src family kinases and Syk, expressed on neutrophils, monocytes, macrophages, platelets, and dendritic cells. CD32b is encoded by FCGR2B and is an inhibitory receptor with an immunoreceptor tyrosine based inhibitory motif that recruits SHIP and SHP phosphatases, expressed on B cells, monocytes, macrophages, dendritic cells, and some basophils and mast cells, and it constrains antibody mediated activation to maintain tolerance. CD32c is encoded by FCGR2C and can function as an activating receptor depending on its open reading frame status, with expression largely restricted to natural killer cells and some monocytes, and it contributes to antibody dependent cellular cytotoxicity. Genetic polymorphisms in FCGR2A, FCGR2B, and FCGR2C influence IgG subclass binding, receptor signaling strength, and susceptibility to autoimmune disease, infection outcomes, and responses to therapeutic antibodies. Clinical interest includes using CD32 isoforms as biomarkers and as targets to tune effector functions in antibody therapies.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CD32; CD32A; CD32B; CD32C; CDw32; Fc fragment of IgG receptor IIa; Fc fragment of IgG receptor IIb; Fc fragment of IgG receptor IIc; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity IIc, receptor for (CD32); Fc gamma receptor IIC; Fc gamma receptor RIIa3; Fc gamma RIIb; Fc-gamma RII-a; Fc-gamma RII-b; Fc-gamma RII-c; Fc-gamma-RIIa; Fc-gamma-RIIb; Fc-gamma-RIIc; FCG2A; FCG2B; FCG2C; FCGR2B; FcgRIIa3 splice variant; fcRII-a; fcRII-b; FcyRIIA; FcyRIIB; FcyRIIC; IGFR2A; IgG Fc fragment receptor; IgG Fc fragment receptor precursor; IgG Fc receptor alpha-Fc-gamma-RII; IgG Fc receptor beta-Fc-gamma-RII; IgG Fc receptor II-a; IgG Fc receptor II-b; IgG Fc receptor II-c; IgG Fc receptor precursor; Immunoglobulin G Fc receptor II; immunoglobulin G Fc receptor II-c; Low affinity immunoglobulin gamma Fc region receptor II-a; Low affinity immunoglobulin gamma Fc region receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II-c; unnamed protein product

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基因别名: CD32; CD32A; CD32B; CD32C; CDW32; FCG2; FcgammaRIIa; FcgammaRIIb; FcgammaRIIc; FcGR; FCGR2; FCGR2A; FCGR2A1; FCGR2B; FCGR2C; FcGRIIB; FcRII-c; FCRIIC; IGFR2

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UniProt ID: (Human) P12318, (Human) P31994, (Human) P31995

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Entrez Gene ID: (Human) 2212, (Human) 2213, (Human) 9103

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功能
protein binding IgG receptor activity IgG binding beta-amyloid binding low-affinity IgG receptor activity macromolecular complex binding transmembrane signaling receptor activity
参与通路
antibody-dependent cellular cytotoxicity regulation of immune system process immune response cell surface receptor signaling pathway positive regulation of tumor necrosis factor production Fc-gamma receptor signaling pathway positive regulation of phagocytosis negative regulation of type I hypersensitivity negative regulation of antibody-dependent cellular cytotoxicity negative regulation of cytokine production immune effector process follicular dendritic cell activation mature B cell differentiation involved in immune response follicular B cell differentiation immune complex clearance by monocytes and macrophages negative regulation of dendritic cell antigen processing and presentation regulation of B cell antigen processing and presentation negative regulation of immunoglobulin production regulation of adaptive immune response negative regulation of acute inflammatory response to antigenic stimulus positive regulation of humoral immune response negative regulation of humoral immune response mediated by circulating immunoglobulin receptor-mediated endocytosis phagocytosis phagocytosis, engulfment defense response inflammatory response response to bacterium immunoglobulin mediated immune response antigen processing and presentation of exogenous peptide antigen via MHC class II cerebellum development negative regulation of B cell proliferation negative regulation of interleukin-10 production negative regulation of macrophage activation negative regulation of cytotoxic T cell degranulation regulation of innate immune response mast cell activation positive regulation of JNK cascade negative regulation of phagocytosis negative regulation of immune response negative regulation of B cell receptor signaling pathway negative regulation of B cell activation cellular response to molecule of bacterial origin regulation of immune complex clearance by monocytes and macrophages negative regulation of neutrophil activation regulation of dendritic spine maintenance regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway cellular response to beta-amyloid positive regulation of response to endoplasmic reticulum stress negative regulation of dendritic cell differentiation immune system process
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