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Invitrogen
CD354 (TREM-1) Monoclonal Antibody (L5-B8.2A12.3A12), PE
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产品信息
MA5-28221
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
L5-B8.2A12.3A12
抗原
Mouse TREM-1 Fc fusion protein
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Lyophilized
浓度
Conc. Not Determined
纯化类型
Protein G
保存液
PBS with 1% BSA, 5% sucrose
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 1.0 mL distilled water
Rat anti Mouse Trem-1 antibody, clone L5-B8.2A12.3A12 recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes.
靶标信息
TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD354; sCD354; soluble CD354; soluble TREM 1; soluble TREM1; sTREM 1; sTREM1; TREM; TREM-1; triggering receptor expressed in monocytes 1; Triggering receptor expressed on myeloid cells; Triggering receptor expressed on myeloid cells 1
基因别名: Trem1
UniProt ID: (Mouse) Q9JKE2
Entrez Gene ID: (Mouse) 58217
positive regulation of defense response to virus by host
cytokine secretion involved in immune response
cell migration
neutrophil chemotaxis
cytokine metabolic process
chemokine metabolic process
neutrophil mediated killing of gram-negative bacterium
neutrophil extravasation
mitophagy in response to mitochondrial depolarization
