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Invitrogen
CD355 (CRTAM) Monoclonal Antibody (Cr24.1), Alexa Fluor™ 488, eBioscience™
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CD355 (CRTAM) Antibody (53-3559-42) in Flow
Normal human peripheral blood cells were unstimulated (left) or stimulated for 4 hours with the Cell Stimulation Cocktail (Product # 00-4970-93) (right). Cells were then stained with CD8 Monoclonal Antibody, APC (Product # 17-0088-42) and CD355 Monoclonal Antibody, Alexa Fluor 488. Cells in the lymphocyte gate were used for analysis.
产品信息
53-3559-42
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
Cr24.1
偶联物
激发/发射光谱
499/520 nm
查看光谱
形式
Liquid
浓度
5 µL/Test
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with BSA
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Description: This monoclonal antibody Cr24.1 reacts with human CD355, also known as Class-I MHC-restricted T-cell-associated molecule (CRTAM). CD355 usually exists as a homodimer, however, it forms a heterodimer with its ligand Necl-2. CD355 is transiently expressed by activated NK, NKT, gamma delta T, and CD8+ T cells. CD355 is also expressed by Purkinje neurons. Human CD355 is involved in immunosurveillance of cancer cells, gamma delta T cell survival, cell polarity, retention of lymphocytes in lymph nodes, promotion of cytotoxicity in NK cells, and IFN gamma secretion from CD8+ T cells. Cr24.1 has been reported to have antagonist activity.
Applications Reported: This CR24.1 antibody has been reported for use by flow cytometric analysis.
Applications Tested: This CR24.1 antibody has been pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells. This may be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser
靶标信息
Class-I MHC-restricted T cell-associated molecule (CRTAM) is a gene located on chromosome 11q24.2, encoding a member of the immunoglobulin superfamily that plays a crucial role in immune cell interactions. CRTAM is expressed on activated CD8+ T cells, natural killer (NK) cells, and some subsets of CD4+ T cells, where it is involved in promoting cell adhesion, cytokine production, and cytotoxic responses. The protein binds to Necl-2 (CD112), mediating intercellular communication that influences immune responses, particularly in the context of viral infections and tumor surveillance. CRTAM's involvement in directing immune cell activity highlights its importance in the regulation of adaptive and innate immunity. Research into CRTAM is exploring its potential as a therapeutic target for modulating immune functions, aiming to enhance immune responses against cancer and infectious diseases or to attenuate autoimmune reactions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
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生物信息学
蛋白别名: CD355; CD355 antigen; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; Class-I MHC-restricted T-cell-associated molecule; cytotoxic and regulatory T cell molecule; Cytotoxic and regulatory T-cell molecule
基因别名: CD355; CRTAM
UniProt ID: (Human) O95727
Entrez Gene ID: (Human) 56253
T cell mediated cytotoxicity
detection of tumor cell
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cell recognition
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of cytokine secretion
regulation of immune response
activated T cell proliferation
detection of stimulus
