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Invitrogen
CD357 (AITR/GITR) Recombinant Rabbit Monoclonal Antibody (PSH04-06)
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CD357 (AITR/GITR) Antibody (MA571396) in ICC/IF
Immunofluorescence analysis of GITR using HUT 102. The cells were fixed in 4% paraformaldehyde for 20 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 5 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. The cells were co-labeled with CD357 (AITR/GITR) Recombinant Rabbit Monoclonal Antibody (PSH04-06) (Product # MA5713... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA571396
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH04-06
抗原
Recombinant protein within human GITR aa 1-162 / 241.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control: HUT 102 cell lysates, HUT 102.
Tissue Specificity: Tissue enhanced (skin).
Subcellular Location: Cell membrane; Secreted.
Predicted band size: 26 kDa.
靶标信息
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activation-inducible TNFR family receptor; AITR; GITR; TNF receptor homolog; similar to murine glucocorticoid-induced TNFR-related protein; glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; UNQ319; variant (4) contains an extra coding segment, which leads to a frame shift, compared to variant 1 and 3; resulting protein (isoform 4) contains a transmembrane domain (identical to variant 1 and 3) and a longer cytoplasmic domain with a sequence different
基因别名: AITR; CD357; ENERGEN; GITR; GITR-D
UniProt ID: (Human) Q9Y5U5
Entrez Gene ID: (Human) 8784
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