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Invitrogen
CD369 (Clec7a, Dectin-1) Polyclonal Antibody
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产品信息
PA5-87072
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide of human CLEC7A.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beta-glucan receptor; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; CD369; DC-associated C-type lectin 1; dectin-1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1
基因别名: beta-GR; BGR; CANDF4; CD369; CLEC7A; Clec7b; CLECSF12; DECTIN1; RGD1565140; SCARE2; UNQ539/PRO1082
UniProt ID: (Human) Q9BXN2
Entrez Gene ID: (Human) 64581, (Mouse) 56644, (Rat) 502902
response to yeast
detection of yeast
pattern recognition receptor signaling pathway
response to molecule of fungal origin
leukocyte activation involved in immune response
immune system process
cell surface pattern recognition receptor signaling pathway
phagocytosis, recognition
phagocytosis, engulfment
inflammatory response
cell recognition
single organismal cell-cell adhesion
positive regulation of tumor necrosis factor production
innate immune response
positive regulation of phagocytosis
cellular response to molecule of fungal origin
stimulatory C-type lectin receptor signaling pathway
carbohydrate mediated signaling
T cell activation
defense response to protozoan
