Invitrogen

CD4/CD28 Antibody Cocktail, FITC, PE

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说明书
实验方案
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说明书
实验方案
问题与答案
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产品信息

MA1-12122

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Cocktail

类型

Antibody

克隆号

7E14, B-23

抗原

human peripheral blood T lymphocytes and HPB-ALL T-cell line

偶联物

FITC , PE FITC , PE FITC , PE

形式

Liquid

纯化类型

Protein A/G

保存液

PBS with 0.2% carrier protein

内含物

0.08% sodium azide

保存条件

4°C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1072293

产品详细信息

This antibody is a monoclonal mixture of FITC-conjugated CD4 (clone 7E14, isotype IgG1) and PE-conjugated CD28 (clone B-23, isotype IgG1).

靶标信息

The CD4 antigen is involved in the recognition of the type II MHC antigen. It is also a receptor for HIV. It is present on most T helper cells and normal thymocytes. The cytoplasmic portion of CD4 is associated with p56lck tyrosine kinase. CD4 expression is commonly found in human lymph nodes and tonsils. Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells and 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: CD28; CD28 antigen; CD4; CD4 antigen (p55); CD4 antigen p55; CD4 receptor; MGC138290; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell-specific surface glycoprotein CD28; TP44

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基因别名: CD28; CD4; CD4mut; Tp44

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UniProt ID: (Human) P10747, (Human) P01730

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Entrez Gene ID: (Human) 940, (Human) 920

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功能
protease binding SH3/SH2 adaptor activity protein binding coreceptor activity protein kinase binding identical protein binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity virus receptor activity glycoprotein binding receptor activity transmembrane signaling receptor activity extracellular matrix structural constituent zinc ion binding immunoglobulin binding enzyme binding MHC class II protein binding protein homodimerization activity protein tyrosine kinase binding immunoglobulin receptor superfamily
参与通路
positive regulation of inflammatory response to antigenic stimulus humoral immune response cell surface receptor signaling pathway positive regulation of gene expression negative regulation of gene expression regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling T cell costimulation positive regulation of interleukin-10 production positive regulation of interleukin-4 production cytokine biosynthetic process positive regulation of T cell proliferation negative thymic T cell selection regulatory T cell differentiation positive regulation of viral genome replication positive regulation of interleukin-2 biosynthetic process regulation of regulatory T cell differentiation positive regulation of translation positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter positive regulation of alpha-beta T cell proliferation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling positive regulation of isotype switching to IgG isotypes regulation of defense response to virus by virus T cell receptor signaling pathway positive regulation of protein kinase B signaling apoptotic signaling pathway cytokine production adaptive immune response induction by virus of host cell-cell fusion immune response signal transduction enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of calcium ion transport into cytosol fusion of virus membrane with host plasma membrane T cell differentiation entry into host cell response to estradiol maintenance of protein location in cell response to vitamin D helper T cell enhancement of adaptive immune response T cell selection positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation
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