Search
Invitrogen
CD4/CD8 Antibody Cocktail, FITC, PE
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
MA5-17009
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a/IgG2b
分类
Cocktail
类型
Antibody
克隆号
YTS191.1/KT15
抗原
Clone YTS191.1: mouse thymocytes. Clone KT15: V beta 11 + T-cell clone
偶联物
FITC , PE
FITC , PE
FITC , PE
形式
Lyophilized
浓度
Conc. Not Determined
纯化类型
purified
保存液
PBS with 1% BSA, 5% sucrose
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-17009 contains a monoclonal mixture of FITC-conjugated CD4 (clone #YTS191.1, Rat IgG2b) and RPE-conjugated CD8 (clone #KT15, Rat IgG2a). This antibody is a dual-color reagent recognizing mouse CD4 and CD8 cell surface antigens. Clone YTS191.1 recognizes murine CD4, a T cell differentiation antigen expressed on thymocytes and helper/inducer T cells in the peripheral blood. Clone KT15 recognizes a non-polymorphic epitope on the murine CD8 alpha chain.
Reconstitute with 1 mL of distilled water. After reconstitution, store product undiluted at 4°C in the dark.
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
靶标信息
CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CD4 antigen p55; CD8 antigen, alpha chain; CD8alpha; CD8beta; L3T4 differentiation antigen protein; L3T4 surface antigen precursor; Leu-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein Lyt-2; unnamed protein product
基因别名: L3T4; Ly-2; Ly-35; Ly-4; Ly-B; Lyt-2
UniProt ID: (Mouse) P06332, (Mouse) P01731
Entrez Gene ID: (Mouse) 12504, (Mouse) 12525
virus receptor activity
receptor binding
protein binding
zinc ion binding
lipid binding
coreceptor activity
immunoglobulin binding
enzyme binding
protein kinase binding
MHC class II protein complex binding
interleukin-16 binding
interleukin-16 receptor activity
MHC class II protein binding
identical protein binding
protein homodimerization activity
protein tyrosine kinase binding
MHC class I protein complex binding
adaptive immune response
T cell mediated immunity
cell surface receptor signaling pathway
T cell activation
cytotoxic T cell differentiation
positive regulation of calcium-mediated signaling
T cell receptor signaling pathway
defense response to virus
immune response
cell adhesion
positive regulation of calcium ion transport into cytosol
T cell differentiation
macrophage differentiation
maintenance of protein location in cell
helper T cell enhancement of adaptive immune response
interleukin-15-mediated signaling pathway
positive regulation of T cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
T cell selection
positive regulation of monocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of viral entry into host cell
viral entry into host cell
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-negative bacterium
regulation of T cell activation
positive regulation of T cell activation
regulation of calcium ion transport
positive regulation of ERK1 and ERK2 cascade
cellular response to granulocyte macrophage colony-stimulating factor stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
