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Invitrogen
CD44 Monoclonal Antibody (YKIX337.8), FITC, eBioscience™
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产品信息
11-5440-42
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog
已发表种属
Dog
宿主/亚型
Rat
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
YKIX337.8
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
5 µL/Test
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with BSA
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Description: This YKIX337.8 monoclonal antibody reacts with canine CD44, also known as phagocytic glycoprotein-1 (Pgp-1). CD44 is an adhesion molecule that binds hyaluronan, a major component of the extracellular matrix. This cell surface molecule is expressed on leukocytes and epithelial cells, as well as in canine mammary and melanocytic tumors. Furthermore, CD44 expression is induced by T cell activation.
Applications Reported: This YKIX337.8 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This YKIX337.8 antibody has been pre-titrated and tested by flow cytometric analysis of normal canine peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
生物信息学
蛋白别名: CD44 molecule; CD44 molecule (Indian blood group); ECMR-III; ECMRIII; extracellular matrix receptor-III; GP90 lymphocyte homing/adhesion receptor; hermes antigen; HUTCH-I; hyaluronan receptor; hyaluronate receptor; PGP I; PGP-1; PGP-I; PGPI; phagocytic glycoprotein 1; phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44
Entrez Gene ID: (Dog) 403939
