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Invitrogen

CD45R (B220) Recombinant Rat Monoclonal Antibody (RA3-6B2)

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产品信息

750020T

应用
建议稀释比
已发表文章

免疫组化（石蜡） (IHC (P))

1:100
-

流式细胞分析 (Flow)

0.015 µg/test
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rat / IgG2a, kappa

Expression System

Expi293

分类

Recombinant Monoclonal

类型

Antibody

克隆号

RA3-6B2

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2-7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

产品详细信息

Recombinant rat monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

靶标信息

CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. Further, these CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. In addition to its role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. Diseases associated with CD45 dysfunction include Severe Combined Immunodeficiency (T-cell negative, B-Cell Negative) and Hepatitis C.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: 200 kDa T-cell leukocyte common antigen isoform; CD45 antigen; CD45; Ly5; glycoprotein 180; glycoprotein isoform Ly-5; leukocyte common antigen; lymphocyte antigen 5; lymphocyte common antigen; protein tyrosine phosphatase; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; T200 glycoprotein; T200 leukocyte common antigen; unnamed protein product

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基因别名: B220; CD45; CD45R; GP180; IMD105; L-CA; LCA; loc; Ly-5; LY5; Lyt-4; T200

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UniProt ID: (Human) P08575, (Mouse) P06800

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Entrez Gene ID: (Human) 5788, (Mouse) 19264

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功能
protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity receptor binding protein binding heparin binding protein kinase binding protein tyrosine kinase inhibitor activity ankyrin binding spectrin binding heparan sulfate proteoglycan binding identical protein binding
参与通路
negative regulation of transcription from RNA polymerase II promoter natural killer cell differentiation negative regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity negative regulation of cytokine-mediated signaling pathway hematopoietic progenitor cell differentiation positive regulation of immunoglobulin production positive regulation of T cell mediated immunity regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of humoral immune response mediated by circulating immunoglobulin negative regulation of protein kinase activity protein dephosphorylation negative regulation of cell adhesion involved in substrate-bound cell migration leukocyte cell-cell adhesion signal transduction response to gamma radiation regulation of gene expression dephosphorylation B cell differentiation T cell differentiation positive regulation of B cell proliferation negative regulation of protein autophosphorylation regulation of interleukin-8 production negative regulation of interleukin-2 production positive regulation of interleukin-2 production positive regulation of tumor necrosis factor production heterotypic cell-cell adhesion T cell proliferation B cell proliferation positive regulation of T cell proliferation positive regulation of MAP kinase activity positive regulation of MAPK cascade cell cycle phase transition plasma membrane raft distribution positive thymic T cell selection negative thymic T cell selection positive regulation of T cell differentiation positive regulation of gamma-delta T cell differentiation negative regulation of JAK-STAT cascade positive regulation of alpha-beta T cell proliferation positive regulation of isotype switching to IgG isotypes bone marrow development stem cell development negative regulation of peptidyl-tyrosine phosphorylation regulation of phagocytosis positive regulation of phagocytosis positive regulation of calcium-mediated signaling T cell receptor signaling pathway B cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of antigen receptor-mediated signaling pathway release of sequestered calcium ion into cytosol defense response to virus regulation of cell cycle positive regulation of Fc receptor mediated stimulatory signaling pathway negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade negative regulation of interleukin-4-mediated signaling pathway positive regulation of hematopoietic stem cell migration positive regulation of stem cell proliferation regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway cell surface receptor signaling pathway T cell activation positive regulation of protein kinase activity negative regulation of microglial cell activation response to aldosterone DN2 thymocyte differentiation
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