Invitrogen

CD45RC Monoclonal Antibody (OX-22), PE

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CD45RC Monoclonal Antibody (OX-22), PE

产品信息

MA5-17462

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

0.1 µg/1x10^6 cells
-
产品规格

种属反应

Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

OX-22

抗原

Phytohaemagglutinin-activated rat lymph node cells
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偶联物

PE PE PE

激发/发射光谱

565/576 nm 查看光谱 spectra

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Protein G

保存液

PBS with 4-5mg/mL BSA

内含物

0.02% sodium azide

保存条件

4°C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2538852

产品详细信息

MA5-17462 targets CD45RC in FACS applications and shows reactivity with Rat samples.

The MA5-17462 immunogen is phytohaemagglutinin-activated rat lymph node cells.

靶标信息

CD45RC (PTPRC) is a protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. It acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, the second affects the substrate specificity of the first. Upon T-cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the gene can result in severe combined immunodeficiency and multiple sclerosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: CD45; L-CA; leucocyte common antigen; Leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; Protein tyrosine phosphatase, receptor-type, c polypeptide; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein

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基因别名: CD45; L-CA; Lca; Ptprc; RT7; T200

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UniProt ID: (Rat) P04157

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Entrez Gene ID: (Rat) 24699

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功能
protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding heparin binding protein kinase regulator activity protein kinase binding heparan sulfate proteoglycan binding extracellular matrix protein protein phosphatase protein modifying enzyme
参与通路
activation of MAPK activity negative regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity negative regulation of cytokine-mediated signaling pathway hematopoietic progenitor cell differentiation immunoglobulin biosynthetic process positive regulation of T cell mediated immunity regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of humoral immune response mediated by circulating immunoglobulin negative regulation of protein kinase activity protein dephosphorylation negative regulation of cell adhesion involved in substrate-bound cell migration leukocyte cell-cell adhesion response to gamma radiation dephosphorylation B cell differentiation T cell differentiation positive regulation of B cell proliferation negative regulation of protein autophosphorylation heterotypic cell-cell adhesion peptidyl-tyrosine dephosphorylation T cell proliferation B cell proliferation positive regulation of T cell proliferation positive regulation of MAPK cascade cell cycle phase transition positive thymic T cell selection negative thymic T cell selection regulation of B cell differentiation positive regulation of T cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of alpha-beta T cell proliferation positive regulation of isotype switching to IgG isotypes bone marrow development stem cell development negative regulation of peptidyl-tyrosine phosphorylation T cell receptor signaling pathway B cell receptor signaling pathway regulation of B cell receptor signaling pathway positive regulation of antigen receptor-mediated signaling pathway release of sequestered calcium ion into cytosol defense response to virus regulation of cell cycle positive regulation of hematopoietic stem cell migration positive regulation of stem cell proliferation regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway
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