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Invitrogen

CD51/CD61 (Tadocizumab Biosimilar) Recombinant Humanized mouse Monoclonal Antibody

查看其他13个CD51/CD61抗体

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产品信息

MA5-59797

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

Assay-dependent
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-

功能检测 (Functional)

Assay-dependent
-

Surface plasmon resonance (SPR)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Artificial Control / IgG1

Expression System

CHO cells

分类

Recombinant Monoclonal

类型

Antibody

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Dry ice (international)

RRID

AB_3682816

产品详细信息

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

靶标信息

CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. This complex binds vitronection at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: antigen CD61; antigen identified by monoclonal antibody L230; CD51; CD61; glycoprotein IIIa precursor; GPIIIa; integrin alpha-5 beta-3; Integrin alpha-V; integrin alphaVbeta3; integrin beta 3; integrin beta chain, beta 3; Integrin beta-3; integrin beta-3 subunit; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); plate glycoprotein IIIa (GPIIIa); Platelet membrane glycoprotein IIIa; unnamed protein product; vitronectin alpha subunit precursor; Vitronectin receptor; Vitronectin receptor subunit alpha

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基因别名: BDPLT16; BDPLT2; BDPLT24; CD51; CD61; GP3A; GPIIIa; GT; GT2; ITGAV; ITGB3; MSK8; VNRA; VTNR

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UniProt ID: (Human) P06756, (Human) P05106

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Entrez Gene ID: (Human) 3685, (Human) 3690

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功能
virus receptor activity opsonin binding fibronectin binding protease binding protein kinase C binding receptor binding integrin binding protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding signaling receptor activity neuregulin binding metal ion binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding protein disulfide isomerase activity platelet-derived growth factor receptor binding enzyme binding identical protein binding vascular endothelial growth factor receptor 2 binding cell adhesion molecule binding fibrinogen binding
参与通路
angiogenesis positive regulation of endothelial cell proliferation positive regulation of cell-matrix adhesion positive regulation of leukocyte migration cell-substrate junction assembly cell adhesion cell-matrix adhesion integrin-mediated signaling pathway embryo implantation blood coagulation regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of fibroblast migration negative regulation of lipid storage negative regulation of low-density lipoprotein particle clearance response to activity smooth muscle cell migration positive regulation of smooth muscle cell migration cell migration platelet activation positive regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway cell-substrate adhesion negative regulation of lipid transport regulation of protein localization regulation of actin cytoskeleton organization cell adhesion mediated by integrin positive regulation of cell adhesion mediated by integrin positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading tube development wound healing, spreading of epidermal cells response to platelet-derived growth factor cellular response to platelet-derived growth factor stimulus apolipoprotein A-I-mediated signaling pathway wound healing apoptotic cell clearance regulation of bone resorption positive regulation of angiogenesis positive regulation of bone resorption viral entry into host cell platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation mesodermal cell differentiation positive regulation of smooth muscle cell proliferation negative regulation of lipoprotein metabolic process regulation of developmental process negative chemotaxis regulation of transport regulation of release of sequestered calcium ion into cytosol regulation of serotonin uptake angiogenesis involved in wound healing regulation of biological quality positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to mechanical stimulus cellular response to xenobiotic stimulus positive regulation of glomerular mesangial cell proliferation blood coagulation, fibrin clot formation maintenance of postsynaptic specialization structure regulation of postsynaptic neurotransmitter receptor internalization regulation of postsynaptic neurotransmitter receptor diffusion trapping positive regulation of substrate adhesion-dependent cell spreading positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway positive regulation of vascular endothelial growth factor signaling pathway regulation of trophoblast cell migration regulation of extracellular matrix organization cellular response to insulin-like growth factor stimulus negative regulation of endothelial cell apoptotic process positive regulation of T cell migration blood vessel development vasculogenesis formation of primary germ layer positive regulation of cytosolic calcium ion concentration tissue development endodermal cell differentiation positive regulation of cell adhesion regulation of phagocytosis positive regulation of small GTPase mediated signal transduction ERK1 and ERK2 cascade calcium ion transmembrane transport transforming growth factor beta production entry into host cell by a symbiont-containing vacuole extrinsic apoptotic signaling pathway in absence of ligand cell-cell adhesion positive regulation of intracellular signal transduction negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway
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