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CD56 Antibody (PA5-115622) in ICC/IF
Immunocytochemistry analysis of CD56 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115622) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115622
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NCAM1(Accession P13591), corresponding to amino acid residues A778-E828.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900257
产品详细信息
Antibody detects endogenous levels of total NCAM1.
靶标信息
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa. CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. Polysialic modification results in reduction of CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins. CD56 is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma. Further, CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: antigen recognized by monoclonal antibody 5.1H11; CD-56; CD56; E NCAM; N CAM1; N-CAM-1; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
基因别名: CD56; E-NCAM; MSK39; NCAM; NCAM-1; NCAM1
UniProt ID: (Human) P13591, (Mouse) P13595
Entrez Gene ID: (Human) 4684, (Mouse) 17967
MAPK cascade
cell adhesion
axon guidance
positive regulation of GTPase activity
viral entry into host cell
regulation of synaptic plasticity
interferon-gamma-mediated signaling pathway
regulation of exocyst assembly
cell surface receptor signaling pathway
aging
learning or memory
response to lead ion
response to fluoxetine
thalamus development
neuron projection development
multicellular organismal response to stress
homotypic cell-cell adhesion
response to cocaine
neuron development
positive regulation of calcium-mediated signaling
regulation of sensory perception of pain
positive regulation of cardiac muscle cell proliferation
negative regulation of cell death
