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Invitrogen
CD6 Monoclonal Antibody (MEM-98), PE
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CD6 Antibody (MA1-10258) in Flow
Flow cytometry analysis of CD6 in human blood. Samples were stained with CD6 PE monoclonal antibody (Product # MA1-10258) using a dilution of 1 μg/mL. Separation of human CD6 positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA1-10258
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
MEM-98
抗原
Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone) (aa 125-128).
偶联物
PE
PE
PE
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
0.03 mg/mL
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody reacts with an extracellular epitope of CD6, a 100-130 kDa single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells.
靶标信息
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD6; CD6 antigen; FLJ44171; T-cell differentiation antigen CD6; T12; TP120; unnamed protein product
基因别名: CD6; TP120
Entrez Gene ID: (Human) 923
immunological synapse formation
acute inflammatory response to antigenic stimulus
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
vesicle-mediated transport
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
positive regulation of T cell proliferation
positive regulation of cytokine production involved in inflammatory response
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
