Invitrogen

CD63 Polyclonal Antibody

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17个已发表图片
26 篇参考文献
查看其他95个CD63抗体

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说明书
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问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
CD63 Polyclonal Antibody

产品信息

PA5-92370

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:100-1:500
查看20篇已发表文章 20篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:50-1:100
-

流式细胞分析 (Flow)

-
查看1篇已发表文章 1篇已发表文章

酶联免疫吸附实验 (ELISA)

1 µg/mL
-

免疫电镜技术 (IM)

-
查看1篇已发表文章 1篇已发表文章

亲和纯化 (AP)

-
查看4篇已发表文章 4篇已发表文章
产品规格

种属反应

Human

已发表种属

C. elegans, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein (or fragment)
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.45 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2806456

产品详细信息

Immunogen sequence: AGYVFRDKVM SEFNNNFRQQ MENYPKNNHT ASILDRMQAD FKCCGAANYT DWEKIPSMSK NRVPDSCCIN VTVGCGINFN EKAIHKEGCV EKIGGWLRKN V; Positive Samples: A375, 22Rv1, Mouse kidney, Mouse spleen; Cellular Location: Cell membrane, Endosome, Late endosome membrane, Lysosome membrane, Melanosome, Multi-pass membrane protein, multivesicular body

靶标信息

CD63, also known as LAMP-3, is a glycoprotein belonging to the tetraspanin family, primarily located in late endosomes, lysosomes, and secretory vesicles across various cell types. It is expressed intracellularly in resting platelets and basophils, but upon activation, CD63 translocates to the plasma membrane, making it a widely used marker for basophil activation. Unlike basophils, mast cells can expose CD63 without activation. CD63 is expressed on activated platelets, monocytes, macrophages, and granulocytes, as well as endothelial cells, fibroblasts, and smooth muscle cells. It interacts with integrins (such as VLA-3 and VLA-6) and TIMP-1, playing roles in mediating allergic responses, phagocytosis, and cell migration. Additionally, CD63 is involved in the regulation of H/K-ATPase trafficking and ROMK1 channels, and serves as a T-cell costimulation molecule. CD63 expression can be used to predict prognosis in early-stage carcinomas and is identical to the melanoma-associated antigen ME491 and the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome, highlighting its significance in both immune responses and disease processes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CD 63; CD63; CD63 antigen; CD63 antigen (melanoma 1 antigen); Granulophysin; LAMP-3; Limp1; Lysosomal-associated membrane protein 3; Lysosome integral membrane protein 1; lysosome-associated membrane glycoprotein 3; Melanoma-associated antigen ME491; melanoma-associated antigen MLA1; Ocular melanoma-associated antigen; OMA81H; Tetraspanin-30; Tspan-30

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基因别名: CD63; LAMP-3; ME491; MLA1; OMA81H; TSPAN30

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UniProt ID: (Human) P08962

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Entrez Gene ID: (Human) 967

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