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Invitrogen
CD81 Recombinant Rabbit Monoclonal Antibody (PSH10-26)
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CD81 Antibody (MA570116) in IHC (P)
Immunohistochemistry analysis of CD81 in paraffin-embedded human liver tissue. Samples were incubated with CD81 monoclonal antibody (Product # MA570116) using a dilution of 1:1,000 for 1 hour at room temperature. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with d... View More
产品信息
MA570116
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH10-26
抗原
Recombinant protein within human CD81 aa 34-201.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive control: Raji cell lysate, HL-60 cell lysate, U-937 cell lysate, PC-12 cell lysate, HCT 116 cell lysate, human liver tissue, Jurkat.
Subcellular location: Cell membrane, Basolateral cell membrane.
靶标信息
CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T cells. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Like members of the tetraspanin family that include CD9, CD37, CD53, CD63, and CD82, CD81 is a cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD81 is a cell surface glycoprotein that is known to complex with integrins. CD81 appears to promote muscle cell fusion and support myotube maintenance. CD81 associates with CD19, CD21, Leu 13, and integrins on cell membrane and acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. CD81 is also localized in the tumor-suppressor gene region and is a candidate gene for malignancies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 26 kDa cell surface protein TAPA-1; 26-kDa cell surface protein TAPA-1; CD 81 antigen; CD81; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); Target of the antiproliferative antibody 1; Tetraspanin-28; Tetraspanin28; Tspan-28
基因别名: CD81; CVID6; S5.7; TAPA1; TSPAN28
UniProt ID: (Human) P60033
Entrez Gene ID: (Human) 975, (Rat) 25621
activation of MAPK activity
phosphatidylinositol biosynthetic process
protein localization
positive regulation of cell proliferation
response to wounding
positive regulation of B cell proliferation
regulation of growth
regulation of cell proliferation
positive regulation of 1-phosphatidylinositol 4-kinase activity
phosphatidylinositol metabolic process
positive regulation of peptidyl-tyrosine phosphorylation
regulation of cell motility
immunological synapse formation
adaptive immune response
immune system process
humoral immune response mediated by circulating immunoglobulin
positive regulation of inflammatory response to antigenic stimulus
myoblast fusion involved in skeletal muscle regeneration
receptor internalization
regulation of protein stability
macrophage fusion
CD4-positive, alpha-beta T cell costimulation
positive regulation of MAPK cascade
positive regulation of transcription from RNA polymerase II promoter
viral entry into host cell
positive regulation of B cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
positive regulation of B cell activation
protein localization to lysosome
positive regulation of protein exit from endoplasmic reticulum
cellular response to low-density lipoprotein particle stimulus
protein localization to plasma membrane
osteoclast fusion
positive regulation of receptor clustering
positive regulation of protein catabolic process in the vacuole
regulation of macrophage migration
positive regulation of adaptive immune memory response
positive regulation of T-helper 2 cell cytokine production
positive regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
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