NeoBiotechnologies

CD86 (Dendritic Cells Maturation Marker) Monoclonal Antibody (C86/1146)

Name: CD86 (Dendritic Cells Maturation Marker) Monoclonal Antibody (C86\/1146)
Brand: NeoBiotechnologies
SKU: 942-MSM2-P0

查看其他140个CD86抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (4)

CD86 (Dendritic Cells Maturation Marker) Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 4

CD86 (Dendritic Cells Maturation Marker) Antibody (942-MSM2-P0) in ICC/IF

Confocal Immunofluorescence image of Raji cells using CD86 Mouse Monoclonal Antibody (C86/1146) followed by goat anti-Mouse IgG conjugated with CF488 (green). Red Dot is used to label the Nuclei (red).

CD86 (Dendritic Cells Maturation Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CD86 (Dendritic Cells Maturation Marker) Antibody in Western Blot (WB)

CD86 (Dendritic Cells Maturation Marker) Antibody in SDS-PAGE (SDS-PAGE)

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Immunogen image

Immunogen Image CD86 (Dendritic Cells Maturation Marker) Monoclonal Antibody (C86/1146)

产品信息

942-MSM2-P0

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

免疫组化（石蜡） (IHC (P))

Assay-dependent

免疫组织化学（多聚甲醛固定） (IHC (PFA))

2-4 µg/mL

免疫细胞化学 (ICC/IF)

2-4 µg/mL

免疫电镜技术 (IM)

Assay-dependent

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

C86/1146

抗原

Recombinant human full-length CD86 protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4°C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

CD86, along with CD80, is a member of the B7 family of costimulatory molecules and plays a crucial role in T cell activation and immune response regulation. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells, and its expression is upregulated on B cells through various stimuli, including the BCR complex, CD40, and certain cytokine receptors. As a type I membrane protein and member of the immunoglobulin superfamily, CD86 serves as a ligand for the T cell surface proteins CD28 and CTLA-4 (CD152). The interaction between CD86 and CD28 provides a costimulatory signal essential for T cell activation during antigen presentation, while binding with CTLA-4 negatively regulates T cell activation, diminishing the immune response. This interaction is critical for T-B cell crosstalk, T cell costimulation, autoantibody production, and Th2-mediated Ig production. The kinetics of CD86 upregulation upon stimulation suggest its significant contribution during the primary phase of an immune response. CD86 and CD80 have distinct roles in T helper cell differentiation, and insufficient co-stimulation involving these molecules can induce tolerance. Alternative splicing of CD86 results in two transcript variants encoding different isoforms, with additional variants described but not fully sequenced. Dysfunction in CD86 is associated with diseases such as gallbladder squamous cell carcinoma and myocarditis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Activation B7-2 antigen; B lymphocyte activation antigen B72; B-lymphocyte activation antigen B7-2; B70; BU63; CD28 antigen ligand 2; CD86; cd86 antigen; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CTLA-4 counter-receptor B7.2; early T cell costimulatory molecule-1; Early T-cell co-stimulatory molecule 1; Early T-cell costimulatory molecule 1; ETC-1; FUN-1; membrane glycoprotein; MGC34413; T-lymphocyte activation antigen CD86

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基因别名: B7; B7-2; B7.2; B70; Cd28l2; CD28LG2; CD86; CLS1; ETC-1; LAB72; Ly-58; Ly58; MB7; MB7-2; TS/A-2

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UniProt ID: (Human) P42081, (Mouse) P42082

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Entrez Gene ID: (Human) 942, (Rat) 56822, (Mouse) 12524

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功能

virus receptor activity receptor activity receptor binding protein binding coreceptor activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity immunoglobulin receptor superfamily

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