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Invitrogen
CD89 Monoclonal Antibody (A59), FITC
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产品信息
MA5-28546
产品规格
种属反应
Cynomolgus monkey,
Human,
Non-human primate,
Rhesus monkey
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
A59
抗原
Ag8.653 myeloma cells
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.08 mg/mL
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes an extracellular epitope of CD89, a 55-100 kDa glycoprotein serving as a receptor for IgA and expressed mainly on granulocytes, monocytes and macrophages.
Recommended dilution is for 100 µL of whole blood or 1x10^6 cells in suspension.
靶标信息
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD89; Fc fragment of IgA receptor; Fc fragment of IgA, receptor for; IgA Fc receptor; IgA Fc receptor Fc alpha Rla2 variant; immunoglobulin A Fc receptor; immunoglobulin A Fc receptor transcript variant deltaEC1 delta TM/C; Immunoglobulin alpha Fc receptor; unnamed protein product
基因别名: CD89; CTB-61M7.2; FcalphaR; FcalphaRI; FCAR
UniProt ID: (Human) P24071
Entrez Gene ID: (Human) 2204, (Cynomolgus monkey) 102145896, (Rhesus monkey) 664734
neutrophil mediated immunity
immune response-regulating signaling pathway
immune response
positive regulation of neutrophil apoptotic process
cellular response to interferon-alpha
Fc receptor signaling pathway
neutrophil activation
cellular response to lipopolysaccharide
cellular response to interferon-gamma
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to granulocyte macrophage colony-stimulating factor stimulus
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