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NeoBiotechnologies
CD95/FAS/TNFRSF6 Monoclonal Antibody (FAS, 3112)
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产品信息
355-MSM2-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
FAS, 3112
抗原
Recombinant fragment (around aa26-96) of human CD95 (FAS) protein
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
CD95, also known as Fas or APO-1, is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor in the tumor necrosis factor receptor (TNFR) superfamily. It is expressed by a wide range of hematopoietic and non-hematopoietic cells, including monocytes, neutrophils, lymphocytes, and fibroblasts. CD95 also exists in a soluble form weighing approximately 26 kDa. The interaction of CD95 with its ligand, FasL, induces apoptosis, playing a crucial role in peripheral tolerance and anti-viral immune responses. Upon stimulation, CD95 leads to the aggregation of its intracellular Fas-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases. This cascade results in apoptosis. CD95 is also involved in activating NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and transduces proliferative signals in normal diploid fibroblasts and T cells. There are at least eight alternatively spliced transcript variants encoding seven distinct isoforms of CD95. Isoforms lacking the transmembrane domain may negatively regulate apoptosis mediated by the full-length isoform. The Fas/Fas ligand system is implicated in several human diseases, including AIDS, hepatitis, and cancer, highlighting its importance in immune regulation and disease pathology.
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生物信息学
蛋白别名: Apo-1 antigen; APO-1 cell surface antigen; Apo-1 Fas; Apo1 antigen; apoptosis antigen 1; apoptosis signaling receptor FAS; Apoptosis-mediating surface antigen FAS; CD95; CD95 antigen; Fas (TNF receptor superfamily, member 6); Fas AMA; FASLG receptor; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; TNF receptor superfamily member 6; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6
基因别名: ALPS1A; APO-1; APT1; CD95; FAS; FAS1; FASTM; TNFRSF6
UniProt ID: (Human) P25445
Entrez Gene ID: (Human) 355
ovarian follicle atresia
immunoglobulin production
renal system process
protein complex assembly
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
activation-induced cell death of T cells
inflammatory cell apoptotic process
inflammatory response
immune response
signal transduction
spermatogenesis
brain development
aging
circadian rhythm
extrinsic apoptotic signaling pathway via death domain receptors
response to toxic substance
gene expression
regulation of gene expression
B cell mediated immunity
telencephalon development
dendrite regeneration
positive regulation of protein homooligomerization
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
response to drug
ovulation cycle
regulation of apoptotic process
chordate embryonic development
positive regulation of apoptotic process
negative regulation of apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAPK cascade
response to peptide hormone
negative thymic T cell selection
regulation of lymphocyte differentiation
regulation of myeloid cell differentiation
response to cycloheximide
spleen development
negative regulation of B cell activation
protein homooligomerization
response to glucocorticoid
maternal process involved in female pregnancy
positive regulation of lymphocyte apoptotic process
cellular response to hydrogen peroxide
response to growth factor
cellular response to phenylalanine
cellular response to mechanical stimulus
cellular response to cobalt ion
cellular response to lithium ion
cellular response to glucose stimulus
cellular response to interleukin-1
cellular response to estrogen stimulus
cellular response to hyperoxia
cellular response to hypoxia
cellular response to hydrostatic pressure
motor neuron apoptotic process
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
hepatocyte apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
liver regeneration
necroptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
response to fluoride
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
