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Invitrogen
CDCA8 Polyclonal Antibody
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CDCA8 Antibody (PA5-90486) in WB
Western blot analysis of CDCA8 in extracts of various cell lines. Samples were incubated with CDCA8 Polyclonal antibody (Product # PA5-90486) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-90486
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human CDCA8 (NP_0605711)
偶联物
形式
Liquid
浓度
1.88 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MAPRKGSSRV AKTNSLRRRK LASFLKDFDR EVEIRIKQIE SDRQNLLKEV DNLYNIEILR LPKALREMNW LDYFALGGNK QALEEAATAD LDITEINKLT AEAIQTPLKS AKTRKVIQVD EMIV; Positive Samples: A-549, 293T, Mouse testis, Rat brain; Cellular Location: Chromosome, Cytoplasm, Nucleus, centromere, cytoskeleton, nucleolus, spindle
靶标信息
CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Borealin; Cell division cycle-associated protein 8; Dasra B; Dasra-B; embryonic stem cell-related; hDasra-B; MESrg; Pluripotent embryonic stem cell-related gene 3 protein
基因别名: 4831429J16Rik; AU044747; BOR; BOREALIN; CDCA8; D4Ertd421e; DasraB; MESRGP; PESCRG3
UniProt ID: (Human) Q53HL2, (Rat) Q6AXW0, (Mouse) Q8BHX3
Entrez Gene ID: (Human) 55143, (Rat) 500545, (Mouse) 52276
