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Rockland
CDIP Polyclonal Antibody
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CDIP Antibody (600-401-AJ5) in ICC/IF
Immunofluorescence CDIP antibody. Tissue: Mouse brain tissue. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: CDIP antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: CDIP is nuclear. Staining: CDIP as red fluorescent signal.
产品信息
600-401-AJ5
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-CDIP antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide near the internal region of human CDIP.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell death inducing protein; Cell death involved p53-target; Cell death-inducing p53-target protein 1; Cell death-inducing protein; Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein; LITAF-like protein; Transmembrane protein I1
基因别名: 2700048O17Rik; 5730403B10Rik; AU018521; AW742692; C16orf5; CDIP; CDIP1; I1; LITAFL
UniProt ID: (Human) Q9H305, (Mouse) Q9DB75
Entrez Gene ID: (Human) 29965, (Mouse) 66626
