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Invitrogen
CDK12 Polyclonal Antibody
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CDK12 Antibody (PA5-14462) in ICC/IF
Knockdown of Cyclin-dependent kinase 12 was achieved by transfecting HeLa cells with Cyclin-dependent kinase 12 specific siRNA (Silencer® select Product # S28623, S28622). Immunofluorescence analysis was performed on untransfected HeLa cells (panel a,d), transfected with non-specific scrambled siRNA (panels b,e) and transfected with Cyclin-dependent kinase 12 specific siRNA (panel c,f). Cells were fixed, permeabilized, and labelled with CDK12 Polyclonal Antibody (Product # PA5-14462, 1:100 dilution) followed by Donkey anti-Rabbit IgG (H+L)... View More
产品信息
PA5-14462
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CrkRS (CRK7)
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Size-exclusion - Dialysis, Ammonium sulfate precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with rat based on sequence homology.
靶标信息
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDC2-related kinase 7; CDC2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; Cell division cycle 2-related protein kinase 7; Cell division protein kinase 12; CrkRS; Cyclin-dependent kinase 12; H KIAA0904; hCDK12; protein kinase for splicing component
基因别名: 1810022J16Rik; AI646528; CDK12; CRK7; CRKR; CRKRS; D11Ertd752e; KIAA0904; Pksc
UniProt ID: (Human) Q9NYV4, (Mouse) Q6ZQ27
Entrez Gene ID: (Human) 51755, (Mouse) 69131
protein kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
cyclin binding
nucleotide binding
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
