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Abnova
CDKL5 Monoclonal Antibody (1D9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00006792-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1D9
抗原
CDKL5 (AAH36091, 722 a.a. approximately 831 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: RPDNSFHENN VSTRVSSLPS ESSSGTNHSK RQPAFDPWKS PENISHSEQL KEKEKQGFFR SMKKKKKKSQ TVPNSDSPDL LTLQKSIHSA STPSSRPKEW RPEKISDLQT
靶标信息
CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing by controlling splicing factor dynamics. The mutations in CDKL5 are major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cyclin dependent kinase 5 transcript; RP1-245G19.3; serine/threonine kinase 9; serine/threonine-protein kinase 9; STK9; unnamed protein product
基因别名: CFAP247; DEE2; EIEE2; ISSX; STK9
UniProt ID: (Human) O76039
Entrez Gene ID: (Human) 6792
neuron migration
positive regulation of Rac protein signal transduction
positive regulation of axon extension
regulation of dendrite development
positive regulation of dendrite morphogenesis
modulation of synaptic transmission
regulation of cell cycle
regulation of postsynapse organization
regulation of cilium assembly
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