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Invitrogen
CDKL5 Monoclonal Antibody (CL4888)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-31407
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CL4888
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: AARANSLQLL SPQPGEQLPP EMTVARSSVK ETSREGTSSF HTRQKSEGGV YHDPHSDDGT APKENRHLYN DPVPRRVGSF YRVPSPRPDN SFHENNVSTR VSSLPSESSS GTNHSKRQPA FDP
Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 97%.
靶标信息
CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing by controlling splicing factor dynamics. The mutations in CDKL5 are major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cyclin-dependent kinase-like 5; RP1-245G19.3; Serine/threonine-protein kinase 9
基因别名: CDKL5; STK9
Entrez Gene ID: (Human) 6792
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