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Invitrogen
CDKN2B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-75177
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 100-138 of Human p15 INK4b.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
The four known 15-to 19 kDa INK4 proteins (p15INK4b, p16INK4a, p18INK4c andp19INK4d) bind and inhibit CDK4 and CDK6 but not other CDKs, including cyclin E-Cdk2, cyclin A-Cdk2 and cyclin B-Cdk1. Like the three D-type cyclins, the INK4 genes are expressed in distinct tissue-specific patterns, suggesting that they are not strictly redundant. 5 p18INK4c is expressed during G1 to S transition in the eukaryotic cell division cycle. It is maximally induced as cells enter S-phase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cyclin dependent kinase inhibitor 2B (p15, inhibits CDK4); Cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor p15; cyclin-dependent kinase inhibitor p15INK4b; cyclin-dependent kinase inhibitor protein; MTS-2; Multiple tumor suppressor 2; p14-INK4b; p15-INK4b; p15INK4B
基因别名: AV083695; CDKN2B; Ink4; INK4b; MTS2; p15; p15(INK4b); p15INK4b
UniProt ID: (Mouse) P55271, (Rat) P55272
Entrez Gene ID: (Mouse) 12579, (Rat) 25164
regulation of cyclin-dependent protein serine/threonine kinase activity
G2/M transition of mitotic cell cycle
cell cycle
cell cycle arrest
mitotic cell cycle checkpoint
negative regulation of cell proliferation
positive regulation of transforming growth factor beta receptor signaling pathway
cellular response to extracellular stimulus
cellular response to nutrient
negative regulation of phosphorylation
spleen development
negative regulation of epithelial cell proliferation
negative regulation of protein serine/threonine kinase activity
negative regulation of G1/S transition of mitotic cell cycle
liver development
aging
response to organic cyclic compound
megakaryocyte differentiation
positive regulation of epithelial cell differentiation
response to cytokine
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
