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Invitrogen
CDKN2B (Isoform 2) Polyclonal Antibody
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CDKN2B (Isoform 2) Antibody (PA5-142832) in WB
Western Blot analysis of CDKN2B (Isoform 2) in Human Gastrointestinal cancer lysate (35 µg protein in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide using CDKN2B (Isoform 2) Polyclonal Antibody (Product # PA5-142832) at 1 µg/mL incubated for 1 hour. Detected by chemiluminescence.
产品信息
PA5-142832
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-RQGARERGARP.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Additional Information: This antibody is expected to recognize isoform 2 (NP_511042.1) only.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
靶标信息
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDK inhibitory protein; CDK4B inhibitor; Cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinases 4 and 6 binding protein; MTS-2; Multiple tumor suppressor 2; p14-INK4b; p14_CDK inhibitor; p14_INK4B; p15 CDK inhibitor; p15-INK4b; p15_INK4B; p15INK4B
基因别名: CDK4I; CDKN2B; INK4B; MTS2; P15; p15INK4b; TP15
UniProt ID: (Human) P42772
Entrez Gene ID: (Human) 1030
regulation of cyclin-dependent protein serine/threonine kinase activity
G2/M transition of mitotic cell cycle
cell cycle arrest
mitotic cell cycle checkpoint
negative regulation of cell proliferation
megakaryocyte differentiation
positive regulation of transforming growth factor beta receptor signaling pathway
cellular response to extracellular stimulus
cellular response to nutrient
negative regulation of phosphorylation
positive regulation of transcription from RNA polymerase II promoter
spleen development
negative regulation of epithelial cell proliferation
negative regulation of protein serine/threonine kinase activity
negative regulation of G1/S transition of mitotic cell cycle
