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Alomone Labs, LTD
CDNF Polyclonal Antibody
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CDNF Antibody (ANT-027-200UL) in IHC (F)
Expression of CDNF in mouse brain - Immunohistochemical staining of immersion-fixed, free floating mouse brain frozen sections using rabbit Anti-CDNF Antibody (#ANT-027), (1:300). A. CDNF staining (green) is detected in several cells in the vicinity of the substantia nigra pars compacta. B. Tyrosine hydroxylase staining (red) appears in the substantia nigra. C. Merge of the two images demonstrates dopaminer... View More
产品信息
ANT-027-200UL
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EKTLDLASVDLRK, corresponding to amino acid residues 129-141 of human CDNF, Mature CDNF protein
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6 OHDA) induced degeneration of dopaminergic neurons in a rat model of Parkinsons disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinsons disease. At least two isoforms of CDNF are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: arginine-rich, mutated in early stage tumors-like 1; ARMET-like protein 1; Cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor
基因别名: 9330140G23; ARMETL1; CDNF
UniProt ID: (Human) Q49AH0, (Mouse) Q8CC36
Entrez Gene ID: (Human) 441549, (Mouse) 227526
