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Invitrogen
CDX1 Recombinant Rabbit Monoclonal Antibody (JG38-50)
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产品信息
MA5-34782
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JG38-50
抗原
Synthetic peptide within Human Cdx1 aa 1-49
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: Human small intestine tissue, CRC.
靶标信息
CDX1, or caudal type homeobox 1, is a gene encoding a homeodomain transcription factor that plays a significant role in the development and differentiation of intestinal epithelial cells. CDX1 is expressed in the intestinal crypts, where it is integral to the Wnt/B-catenin signaling pathway, crucial for cell proliferation. Interestingly, while CDX1 expression is initially active, its expression is often silenced as colon cancer progresses in humans, suggesting a complex role in tumor biology. The CDX1 protein functions as a transcriptional regulator that influences proliferation and differentiation, expressing early during intestinal development. In mice, it is involved in the development of the posterior embryo and is associated with abnormal differentiation in metaplastic and neoplastic tissues, providing insight into intestinal-type gastric adenocarcinoma progression. CDX1 is related to other vertebrate Cdx genes such as Cdx2 and Cdx4, which are homologues of the Drosophila caudal gene and are also implicated in embryonic development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: caudal type homeo box transcription factor 1; caudal type homeobox transcription factor 1; Caudal-type homeobox protein 1; caudal-type homeobox protein CDX1; Homeobox protein CDX-1
基因别名: CDX1
UniProt ID: (Human) P47902
Entrez Gene ID: (Human) 1044
