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Invitrogen
CEACAM1 Polyclonal Antibody
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FIGURE: 1 / 4
CEACAM1 Antibody (PA5-87248) in IHC (P)
Immunohistochemistry analysis of CEACAM1 in paraffin-embedded Human colon carcinoma. Samples were incubated with CEACAM1 polyclonal antibody (Product # PA5-87248) using a dilution of 1:100. Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-87248
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human CEACAM1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
CEACAM1 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent taurocolate-carrier protein; BGP-1; Biliary glycoprotein 1; Biliary glycoprotein D; bone gamma-carboxyglutamic acid (Gla) protein; C-CAM 105; carcinoembryonic antigen 1; carcinoembryonic antigen 7; Carcinoembryonic antigen-related cell adhesion molecule 1; CD66a; CEA cell adhesion molecule 1; CEA-related cell adhesion molecule 1; CEA-related cell adhesion molecule 1 (bone gamma-carboxyglutamic acid (Gla) protein) (osteocalcin); Cell adhesion molecule CEACAM1; Cell-CAM 105; Ecto-ATPase; GP110; hepatitis virus (MHV-4) susceptibility; hepatitis virus receptor; MHV-R; MHVR1; Murine hepatitis virus receptor; osteocalcin; pp120; pp120/ecto-ATPase
Gene Aliases: bb-1; BGP; BGP1; BGPR; C-CAM; Cc1; Ccam1; CD66a; Cea-1; Cea-7; Cea1; Cea7; CEACAM1; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1; mmCGM1; mmCGM1a; mmCGM2
UniProt ID: (Rat) P16573, (Mouse) P31809
Entrez Gene ID: (Rat) 81613, (Mouse) 26365
negative regulation of cytokine production
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
signal transduction
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
negative regulation of interleukin-2 production
positive regulation of T cell proliferation
negative regulation of T cell proliferation
positive regulation of MAP kinase activity
negative regulation by host of viral process
positive regulation by host of viral process
negative regulation by host of viral genome replication
negative regulation of JNK cascade
positive regulation of JNK cascade
viral entry into host cell
Peyer's patch development
positive regulation of immunoglobulin secretion
positive regulation of NFAT protein import into nucleus
protein homotrimerization
positive regulation of activation-induced cell death of T cells
positive regulation of CD4-positive, alpha-beta T cell activation
positive regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of CD8-positive, alpha-beta T cell activation
viral process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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