Bethyl Laboratories

CEACAM1 Recombinant Rabbit Monoclonal Antibody (BLR090G)

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说明书
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CEACAM1 Recombinant Rabbit Monoclonal Antibody (BLR090G)

产品信息

A700-090

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（石蜡） (IHC (P))

1:100 - 1:500
-

免疫细胞化学 (ICC/IF)

1:100 - 1:500
-

流式细胞分析 (Flow)

1 µL per 1 x 10^6 cells
-

免疫沉淀 (IP)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

BLR090G

抗原

Recombinant protein representing the extracellular domain of human CEACAM1 (residues 35-433).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1000 µg/mL

纯化类型

purified

保存液

BBS, pH 7.8 to 8.6

内含物

0.09% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

CEACAM1 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); CD66a; CD66a antigen; CEA cell adhesion molecule 1; Cell adhesion molecule CEACAM1

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基因别名: BGP; BGP1; BGPI; CEACAM1

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UniProt ID: (Human) P13688

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Entrez Gene ID: (Human) 634

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功能
molecular_function actin binding protein binding bile acid transmembrane transporter activity kinase binding protein phosphatase binding filamin binding protein homodimerization activity protein dimerization activity protein tyrosine kinase binding
参与通路
angiogenesis regulation of cell growth blood vessel development negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of protein kinase activity cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules integrin-mediated signaling pathway regulation of endothelial cell migration regulation of phosphatidylinositol 3-kinase signaling bile acid and bile salt transport cell migration regulation of cell migration negative regulation of granulocyte differentiation negative regulation of interleukin-1 production cellular response to insulin stimulus common myeloid progenitor cell proliferation insulin receptor internalization granulocyte colony-stimulating factor signaling pathway regulation of epidermal growth factor receptor signaling pathway negative regulation of vascular permeability negative regulation of cytotoxic T cell degranulation wound healing, spreading of cells regulation of endothelial cell differentiation negative regulation of fatty acid biosynthetic process negative regulation of T cell receptor signaling pathway leukocyte migration negative regulation of lipid biosynthetic process regulation of blood vessel remodeling regulation of ERK1 and ERK2 cascade negative regulation of platelet aggregation cell-cell adhesion insulin catabolic process regulation of homophilic cell adhesion regulation of sprouting angiogenesis negative regulation of hepatocyte proliferation positive regulation of vasculogenesis
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