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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
The antibody detects endogenous levels of total CENPJ protein.
This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CENP-J; Centromere protein J; Centrosomal P4.1-associated protein; Centrosome assembly and centriole elongation protein; LAG-3-associated protein; LYST-interacting protein 1; microcephaly
基因别名: CENPJ; CPAP; LAP; LIP1
Entrez Gene ID: (Human) 55835