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Invitrogen
CHD1L Polyclonal Antibody
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CHD1L Antibody (PA5-115011) in IHC (P)
Immunohistochemistry analysis of CHD1L in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with CHD1L polyclonal antibody (Product # PA5-115011) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-115011
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CHD1L(Accession Q86WJ1), corresponding to amino acid residues R563-L613.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CHD1L.
靶标信息
In response to DNA strand breaks, chromatin adopts a relaxed structure due to the addition of poly(ADP-ribose) (PAR) to chromatin proteins by PARP enzymes (see PARP1; MIM 173870), and this relaxation facilitates the repair of DNA damage. CHD1L interacts with PAR and has a role in chromatin relaxation following DNA damage (Ahel et al., 2009 [PubMed 19661379]).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: amplified in liver cancer 1; Amplified in liver cancer protein 1; chromodomain helicase DNA binding protein 1-like; Chromodomain-helicase-DNA-binding protein 1-like
基因别名: 4432404A22Rik; ALC1; CHD1L; CHDL; Snf2p
UniProt ID: (Human) Q86WJ1, (Mouse) Q9CXF7
Entrez Gene ID: (Human) 9557, (Mouse) 68058
DNA repair
chromatin remodeling
cellular response to DNA damage stimulus
nucleotide-excision repair, DNA duplex unwinding
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
nucleotide-excision repair, DNA incision
global genome nucleotide-excision repair
