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Invitrogen
CHD3 Polyclonal Antibody
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CHD3 Antibody (PA5-77916) in ICC/IF
CHD3 Polyclonal Antibody detects CHD3 protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CHD3 protein stained by CHD3 Polyclonal Antibody (Product # PA5-77916) diluted at 1:500. Blue: Hoechst 33342 staining.
产品信息
PA5-77916
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the N-terminus region of human CHD3. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.76 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: 293T, A431, HeLa
Predicted Reactivity: Mouse (90%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-dependent helicase CHD3; CHD-3; Chromodomain-helicase-DNA-binding protein 3; hZFH; MGC40857; Mi 2a; Mi-2 alpha; Mi-2 autoantigen 240 kDa protein; Mi2 ALPHA; Mi2-alpha; Prp9 1; Zinc finger helicase; zinc-finger helicase (Snf2-like)
基因别名: 2600010P09Rik; AF020312; CHD3; Chd7; Mi-2a; Mi2-ALPHA; Prp7; Prp9-1; ZFH
UniProt ID: (Human) Q12873
Entrez Gene ID: (Human) 1107, (Mouse) 216848
chromatin assembly or disassembly
spindle organization
centrosome organization
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
histone deacetylation
DNA duplex unwinding
regulation of signal transduction by p53 class mediator
