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产品信息
PA5-37148
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to residues in human CHD5
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553931
产品详细信息
This antibody detects endogenous protein at a molecular weight of 230-250 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
CHD5 (Chromodomain helicase DNA binding protein 5) is a member of the SNF2/RAD54 helicase family of chromatin remodeling and DNA-binding proteins (CDH proteins). Heavily expressed in both fetal and adult brain, CHD5 plays a role in nervous system development and acts as a tumor suppressor via the Arf/p53 pathway. CHD5, along with other chromo-domain proteins, forms remodeling complexes, such as NuRD, that promote normal neuroblast maturation and are thought to prevent overexpression of neuronal cells. Errors in these chromatin remodeling complexes can leave the cell in a perpetual state of growth, preventing differentiation and leading to tumor formation. Due to the importance of the CHD proteins in proper brain development, deletions in the gene encoding CHD5 are commonly found in neuroblastomas, suggesting that CHD5 deficiency may lead to malignant cell transformation and metastasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ATP-dependent helicase CHD5; CHD-5; CHD5; Chromodomain-helicase-DNA-binding protein 5
基因别名: 4930532L22Rik; AW060752; B230399N07Rik; CHD-5; CHD5; KIAA0444
UniProt ID: (Human) Q8TDI0
Entrez Gene ID: (Human) 26038, (Mouse) 269610
DNA binding
ATP binding
ATP-dependent helicase activity
zinc ion binding
H3K27me3 modified histone binding
nucleotide binding
nucleic acid binding
chromatin binding
helicase activity
protein binding
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
histone deacetylase binding
metal ion binding
transcription, DNA-templated
negative regulation of cell proliferation
cerebral cortex neuron differentiation
spermatogenesis, exchange of chromosomal proteins
histone H4 acetylation
regulation of transcription involved in cell fate commitment
histone H3-K27 trimethylation
positive regulation of signal transduction by p53 class mediator
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
spermatogenesis
nervous system development
chromatin modification
cell differentiation
regulation of cell differentiation
