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Invitrogen
CHD7 Polyclonal Antibody
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产品信息
PA5-72690
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CHD7 antibody for an 18 amino acid synthetic peptide near the amino terminus of human CHD7. The immunogen is within amino acids 670 - 720 of CHD7.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Chromodomain helicase DNA binding protein 7 (CHD7) is a gene located on chromosome 8q12.2 that encodes a member of the chromodomain helicase DNA-binding (CHD) family, which plays a pivotal role in chromatin remodeling and gene expression regulation. CHD7 contains multiple domains that facilitate its involvement in modifying chromatin structure, thereby influencing the accessibility of DNA for transcription factors and other regulatory proteins. The protein is integral to various developmental processes, including neural crest formation, thus affecting tissues such as the nervous system, skeletal structures, and sensory organs. Mutations in CHD7 are associated with CHARGE syndrome, a multisystem disorder characterized by congenital anomalies including coloboma, heart defects, and ear abnormalities. CHD7's role in chromatin dynamics makes it crucial for normal embryonic development and cellular differentiation. Ongoing research is focused on uncovering CHD7's broader implications in developmental biology and its potential as a therapeutic target in chromatin-related disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-dependent helicase CHD7; CHARGE association; CHD-7; chromodomain helicase DNA binding protein 7 isoform CRA_e; Chromodomain-helicase-DNA-binding protein 7
基因别名: A730019I05Rik; CHD7; CRG; Cycn; Cyn; Dz; Edy; Flo; GENA 47; Gena 52; GENA 60; HH5; IS3; KAL5; KIAA1416; Lda; metis; Mt; Obt; Todo; WBE1; Whi
UniProt ID: (Human) Q9P2D1, (Mouse) Q3TA86
Entrez Gene ID: (Human) 55636, (Mouse) 320790
skeletal system development
blood vessel development
in utero embryonic development
heart morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
rRNA processing
central nervous system development
adult heart development
sensory perception of sound
locomotory behavior
adult walking behavior
blood circulation
chromatin modification
cranial nerve development
olfactory nerve development
olfactory bulb development
T cell differentiation
female genitalia development
embryonic hindlimb morphogenesis
positive regulation of multicellular organism growth
olfactory behavior
ear morphogenesis
inner ear morphogenesis
camera-type eye development
nose development
semicircular canal morphogenesis
genitalia development
artery morphogenesis
regulation of neurogenesis
cognition
palate development
retina development in camera-type eye
regulation of growth hormone secretion
limb development
face development
epithelium development
covalent chromatin modification
