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Invitrogen
CHI3L1 Polyclonal Antibody
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CHI3L1 Antibody (PA5-79042) in WB
Western blot analysis of CHI3L1 in Lane 1: mouse RAW264.7 whole cell lysate, Lane 2: mouse HEPA1-6 whole cell lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minutes. Sample was blocked with 5% Non-fat Milk/TBS for 1.5 hours at room temperature, incubated with CHI3L1 polyclonal antibody (Product # PA5-79042) at a dilution of 0.5 µg/mL (overnight at 4°C),... View More
产品信息
PA5-79042
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived mouse CHI3L1 recombinant protein (Position: Y30-K262).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: mouse RAW2647 whole cell, mouse HEPA1-6 whole cell.
靶标信息
Human cartilage glycoprotein 39 (GP-39), also known as YKL-40, is a glycoprotein secreted by articular chondrocytes, synoviocytes and macrophages. Serum and synovial fluid GP-39 levels are elevated in inflammatory diseases and correlate with the degree of joint destruction in rheumatoid arthritis. GP-39 is expressed in articular chondrocytes and synovial cells, as well as in liver, but is undetectable in muscle tissues, lung, pancreas, mononuclear cells and fibroblasts. GP-39 is a candidate autoantigen in rheumatoid arthritis and is important in the capacity of cells to respond to and cope with changes in their environment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Breast regression protein 39; BRP39 protein; Cartilage glycoprotein 39; CGP-39; CGP39; Chitinase 3 like protein 1CGP 39; chitinase 3-like 1; Chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; GP-39; hCGP39
基因别名: AW208766; Brp39; Chi3l1; Chil1; Gp39
UniProt ID: (Mouse) Q61362
Entrez Gene ID: (Mouse) 12654
carbohydrate metabolic process
chitin catabolic process
apoptotic process
inflammatory response
activation of NF-kappaB-inducing kinase activity
positive regulation of peptidyl-threonine phosphorylation
lung development
positive regulation of angiogenesis
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
interleukin-8 secretion
