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CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2)-specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: acidic chitinase; Acidic mammalian chitinase; AMCase; Lung-specific protein TSA1902; YNL
基因别名: 2200003E03Rik; AMCASE; CHIA; Chia1; CHIT2; TSA1902; YNL
UniProt ID: (Human) Q9BZP6, (Mouse) Q91XA9
Entrez Gene ID: (Human) 27159, (Mouse) 81600