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Invitrogen
CHIL3 Monoclonal Antibody (281926)
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CHIL3 Antibody (MA5-23981) in WB
Western blot analysis of CHIL3 in mouse bone marrow. Samples were incubated in CHIL3 monoclonal antibody (Product # MA5-23981) using a dilution of 0.5 µg/mL followed by a HRP-conjugated Anti-Rat IgG secondary antibody. A specific band was detected for YM1/Chitinase 3-like 3 at approximately 45 kDa (as indicated). This experiment was conducted under reducing conditions.
产品信息
MA5-23981
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
281926
抗原
Mouse myeloma cell line NS0-derived recombinant mouse Chitinase 3-like 3/ECF-L Tyr22-Tyr398
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
The CHIL3 gene encodes the protein chitinase-like 3, which is primarily secreted by macrophages and is involved in immune regulation, tissue remodeling, and inflammatory responses. CHIL3, also known as Ym1, belongs to the chitinase-like protein family but lacks chitinase activity due to mutations in its catalytic domain. It is predominantly expressed in lung tissue, where it plays a vital role in asthmatic responses and allergic inflammation. Furthermore, CHIL3 exerts anti-inflammatory roles during pathogen infection by modulating macrophage pro-inflammatory activity and promoting the Th2 immune response. Beyond immunological involvement, CHIL3 is integral to tissue repair mechanisms and cancer cell proliferation, contributing to extracellular matrix restructuring and angiogenesis. It facilitates macrophage polarization towards an M2 phenotype, which is associated with tumor progression and metastasis. Thus, CHIL3 is considered a potential biomarker for inflammatory diseases and cancer, with ongoing research examining its therapeutic modulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beta-N-acetylhexosaminidase Ym1; chitinase 3-like 3; Chitinase-3-like protein 3; Chitinase-like protein 3; ECF-L; Eosinophil chemotactic cytokine; eosinophil chemotactic factor-L; Secreted protein Ym1
基因别名: AI505981; Chi3l3; Chil3; ECF-L; Ym1
UniProt ID: (Mouse) O35744
Entrez Gene ID: (Mouse) 12655
