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Invitrogen
CHP1 Monoclonal Antibody (OTI1D11)
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CHP1 Antibody (MA5-27264) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded carcinoma of human thyroid tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a CHP1 monoclonal antibody (Product # MA5-27264) at a dilution of 1:250.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-27264
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI1D11
抗原
Full length human recombinant protein of CHP1 produced in HEK293T cell
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calcineurin B homolog; calcineurin B-like protein; calcineurin homologous protein; calcium binding protein P22; calcium-binding protein CHP; calcium-binding protein p22; CHP; EF-hand calcium-binding domain-containing protein p22; SLC9A1 binding protein; unnamed protein product
基因别名: CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9
UniProt ID: (Human) Q99653
Entrez Gene ID: (Human) 11261
microtubule bundle formation
negative regulation of protein phosphorylation
negative regulation of protein kinase activity
protein export from nucleus
potassium ion transport
cellular sodium ion homeostasis
small GTPase mediated signal transduction
positive regulation of glycoprotein biosynthetic process
negative regulation of phosphatase activity
membrane docking
cytoplasmic microtubule organization
negative regulation of protein ubiquitination
negative regulation of protein autophosphorylation
positive regulation of sodium:proton antiporter activity
sodium ion transmembrane transport
regulation of protein import into nucleus
negative regulation of protein import into nucleus
protein stabilization
positive regulation of protein transport
regulation of intracellular pH
membrane organization
membrane fusion
regulation of calcineurin-NFAT signaling cascade
negative regulation of calcineurin-NFAT signaling cascade
positive regulation of phospholipid biosynthetic process
cellular response to acidic pH
positive regulation of protein targeting to membrane
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