Alomone Labs, LTD

CHRM2 Polyclonal Antibody

Name: CHRM2 Polyclonal Antibody
Brand: Alomone Labs, LTD
SKU: AMR-002-200UL

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说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

CHRM2 Antibody in Immunohistochemistry (Frozen) (IHC (F))

图: 1 / 2

CHRM2 Antibody (AMR-002-200UL) in IHC (F)

Expression of Muscarinic acetylcholine receptor M2 in mouse parieto-temporal cortex sections - Immunohistochemical staining of mouse parieto-temporal cortex frozen sections (non-consecutive) using Anti-GIRK2 (Kir3.2) Antibody (#APC-006), (1:100) and Anti-CHRM2 Antibody (#AMR-002), (1:100). mAChR M2 staining (red) was dense in layer IV, with fibers climbing to layers II-III. Kir3.2 K+channel staining (green)... View More

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Immunogen image

Immunogen Image CHRM2 Polyclonal Antibody

产品信息

AMR-002-200UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200

免疫组化（冰冻） (IHC (F))

1:100

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

GST fusion protein with the sequence VANQDPVSPSLVQGRIVKPN NNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSV SAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS DSCTPTNTTVEVVGSSGQNGDE, corresponding to amino acid residues 225-356 of human M2, 3rd intracellular loop

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

Muscarinic cholinergic receptor 2 (CHRM2) is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 7TM receptor; acetylcholine receptor; acetylcholine receptor, muscarinic 2; AChR M2; cholinergic receptor; cholinergic receptor, muscarinic 2; cholinergic receptor, muscarinic 2, cardiac; cholinergic receptor, muscarinic 2, isoform a; FLJ43243; M2 muscarinic acetylcholine receptor; M2-mAChR; m2AChR; MGC120006; MGC120007; muscarinic acetylcholine receptor 2; Muscarinic acetylcholine receptor M2; muscarinic M2 receptor; muscarinic receptor m2

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基因别名: AChR-M2; Acm2; Chrm-2; CHRM2; HM2; M2

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UniProt ID: (Human) P08172, (Mouse) Q9ERZ4, (Rat) P10980

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Entrez Gene ID: (Human) 1129, (Mouse) 243764, (Rat) 81645

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功能

drug binding G-protein coupled acetylcholine receptor activity signal transducer activity G-protein coupled receptor activity G-protein coupled receptor

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