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Alomone Labs, LTD
CHRM4 Polyclonal Antibody
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CHRM4 Antibody (AMR-004-200UL) in ICC/IF
Expression of Muscarinic acetylcholine receptorM4in C6 transfected cells - Immunocytochemical staining of paraformaldehyde-fixed and permeabilized C6 cells. A. Transfected cells were stained using Anti-CHRM4 Antibody (#AMR-004), (1:100) followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Non-transfected cells were stained using Anti-CHRM4 Antibody (1:100), followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). DAPI is used as the counterstain (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
AMR-004-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C) RTLNPASKWSK, corresponding to amino acid residues 330-340 of rat M4 muscarinic receptor, 3rd intracellular loop
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.85 mg/mL
规格
170 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Muscarinic acetylcholine receptor M4 is an Acetylcholine Receptor. Unlike muscarinic receptor M2, the M4 receptor is not involved in smooth muscle contraction. The clinical relevance of this receptor is unknown. However, mouse studies have linked it to adenylyl cyclase inhibition. Muscarinic acetylcholine receptor M4 has been reported to be expressed in many regions of the rat brain, particularly the striatum and hippocampus. ESTs have been isolated from human breast and eye libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetylcholine receptor; acetylcholine receptor, muscarinic 4; cholinergic receptor; cholinergic receptor, muscarin 4; cytotransmitter gated ion channel; G protein coupled receptor; muscarinic acetylcholine receptor 4; muscarinic acetylcholine receptor m4
基因别名: AChR M4; Chrm-4; HM4; M4; M4R; mm4 mAChR
UniProt ID: (Human) P08173, (Mouse) P32211, (Rat) P08485
Entrez Gene ID: (Human) 1132, (Mouse) 12672, (Rat) 25111
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
chemical synaptic transmission
regulation of locomotion
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