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Invitrogen
CHRNA7 Polyclonal Antibody
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CHRNA7 Antibody (PA5-115651) in ICC/IF
Immunocytochemistry analysis of CHRNA7 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115651) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115651
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
C. elegans,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CHRNA7(Accession P36544), corresponding to amino acid residues H18-K68.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total Nicotinic Acetylcholine Receptor alpha 7.
靶标信息
Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChR alpha7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 that is associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder. CHRFAM7A, also known as D-10 or CHRNA7, is a 412 amino acid multi-pass membrane protein that belongs to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, a protein superfamily that mediates signal transmission at synapses. CHRFAM7A is expressed in the hippocampus. Alternative splicing of the CHRFAM7A gene produces two splice variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: a7 nicotinic acetylcholine receptor; acetylcholine receptor; acetylcholine receptor alpha 7 neural; alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; alpha7 nicotinic receptor; alpha7-nAChR; bungarotoxin alpha; C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); cholinergic receptor; cholinergic receptor, nicotinic alpha 7; cholinergic receptor, nicotinic, alpha 7 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 7; CHRFAM7A; CHRNA7-DR1; D-10; nAChR alpha7; neuronal acetylcholine receptor protein, alpha-7 chain; Neuronal acetylcholine receptor subunit alpha-7; neuronal nicotinic acetycholine receptor alpha 7; nicotinic receptor alpha 7 subunit
基因别名: Acra7; alpha7; BTX; CHRNA7; CHRNA7-2; nAchR; NACHRA7; NARAD
UniProt ID: (Human) P36544, (Rat) Q05941, (Mouse) P49582
Entrez Gene ID: (Human) 1139, (Rat) 25302, (Mouse) 11441
beta-amyloid binding
acetylcholine-activated cation-selective channel activity
ligand-gated ion channel activity
acetylcholine receptor activity
toxic substance binding
chloride channel regulator activity
acetylcholine-gated cation channel activity
acetylcholine binding
protein homodimerization activity
protein binding
drug binding
adenylate cyclase binding
protein kinase binding
ATPase binding
scaffold protein binding
ion channel activity
extracellular ligand-gated ion channel activity
ligand-gated ion channel
activation of MAPK activity
response to hypoxia
ion transport
calcium ion transport
cellular calcium ion homeostasis
signal transduction
synaptic transmission, cholinergic
memory
positive regulation of cell proliferation
negative regulation of tumor necrosis factor production
ion transmembrane transport
response to nicotine
positive regulation of angiogenesis
cognition
cation transmembrane transport
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
endocytosis
associative learning
regulation of norepinephrine secretion
neuronal action potential
sperm motility
response to food
regulation of synaptic transmission, dopaminergic
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
behavioral response to nicotine
T cell activation
B cell activation
regulation of membrane potential
dopamine biosynthetic process
ovulation cycle
response to ethanol
behavioral response to ethanol
regulation of inflammatory response
negative regulation of inflammatory response
generation of ovulation cycle rhythm
transport
