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Invitrogen
CHX10 Polyclonal Antibody
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FIGURE: 1 / 1
CHX10 Antibody (PA5-85404) in IHC (P)
Immunohistochemistry (Paraffin) analysis of CHX10 was performed in paraffin-embedded mouse retina tissue. Green: CHX10 stained by CHX10 Polyclonal Antibody (Product # PA5-85404) at a dilution of 1:250. Red: beta Tubulin 3/ Tuj1, a marker, stained by beta Tubulin 3/ Tuj1 antibody. Blue: Fluoroshield with DAPI. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-85404
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse
Published species
Cynomolgus monkey
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human CHX10. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.85 mg/mL
Amount
85 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (95%), Rat (94%), Chicken (84%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CHX10 encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C. elegans ceh-10 homeo domain containing homolog; ceh-10 homeo domain containing homolog; ceh-10 homeodomain containing homolog; ceh-10 homeodomain-containing homolog; homeobox protein; homeobox protein CHX10; ocular retardation; unnamed protein product
Gene Aliases: CHX10; Hox-10; HOX10; MCOP2; MCOPCB3; or; RET1
UniProt ID: (Chicken) Q9IAL1, (Human) P58304, (Mouse) Q61412
Entrez Gene ID: (Chicken) 395536, (Human) 338917, (Mouse) 12677
transcription regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
chromatin binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
sequence-specific double-stranded DNA binding
helix-turn-helix transcription factor
homeodomain transcription factor
DNA-binding transcription factor
gene-specific transcriptional regulator
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
multicellular organism development
visual perception
response to stimulus
negative regulation of transcription from RNA polymerase II promoter
positive regulation of cell proliferation
negative regulation of cell proliferation
camera-type eye development
cell fate commitment
positive regulation of transcription from RNA polymerase II promoter
retinal bipolar neuron differentiation
retina morphogenesis in camera-type eye
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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