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Invitrogen
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By Western blot, PA1-46018 is specific for the ~250 kDa CIC protein.
CIC (~164 kDa) interacts with Ataxin 1 (~87 kDa).
This may explain the band at 250 kDa (complex).Suggested positive control: Hela whole cell extract.
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.
仅用于科研。不用于诊断过程。未经明确授权不得转售。