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Invitrogen
CIS Recombinant Rabbit Monoclonal Antibody (5H6L11)
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CIS Antibody (701832) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized THP-1 cells treated with 10 ng/mL of IL-2 for 16 hours, for detection of CIS using Anti-CIS Recombinant Rabbit Monoclonal Antibody (Product # 701832, 1-2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of CIS protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountan... View More
产品信息
701832
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5H6L11
抗原
Protein corresponding to Human CISH (aa 1-258)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Feline, Rabbit, Rat, Mouse and Goat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
CIS contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CIS; CIS-1; cytokine inducible SH2-containing protein; cytokine-inducible inhibitor of signaling type 1B; Cytokine-inducible SH2-containing protein; Protein G18; SOCS; Suppressor of cytokine signaling
基因别名: BACTS2; CIS; CIS-1; CISH; G18; SOCS
UniProt ID: (Human) Q9NSE2
Entrez Gene ID: (Human) 1154
regulation of cell growth
negative regulation of protein kinase activity
protein kinase C-activating G-protein coupled receptor signaling pathway
protein ubiquitination
cytokine-mediated signaling pathway
intracellular signal transduction
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
