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Invitrogen
CK1 alpha Polyclonal Antibody
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CK1 alpha Antibody (PA5-116673) in IHC (P)
Immunohistochemistry analysis of CK1 alpha in paraffin-embedded human placenta. Samples were incubated with CK1 alpha Polyclonal antibody (Product # PA5-116673) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-116673
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 238-337 of human Casein Kinase 1 alpha (CSNK1A1) (NP_0018834)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.55 mg/mL
规格
155 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: U-87MG, HeLa, MCF7, PC-3, Mouse brain
Immunogen sequence: EKKMSTPVEV LCKGFPAEFA MYLNYCRGLR FEEAPDYMYL RQLFRILFRT LNHQYDYTFD WTMLKQKAAQ QAASSSGQGQ QAQTPTGKQT DKTKSNMKGF
靶标信息
CNSK1A1 (CK1 alpha 1) is a member of the casein kinase I (CKI) gene family, which encodes serine/threonine kinases that preferentially phosphorylate acidic substrates. CKI proteins are monomeric, ranging from 25 to 55 kD, and are found in the nuclei, cytoplasm, and membrane fractions of eukaryotic cells. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Casein kinase I isoform alpha; casein kinase I-alpha; CK I alpha; CK-I alpha; CK1; CKI alpha; CKI-alpha; CSNK1A1/CK1; OTTHUMP00000224000; OTTHUMP00000224001; OTTHUMP00000224003; YIL035C
基因别名: 2610208K14Rik; 4632404G05Rik; 5430427P18Rik; CK1a; Csnk1a; CSNK1A1
UniProt ID: (Rat) P97633, (Mouse) Q8BK63
Entrez Gene ID: (Rat) 113927, (Mouse) 93687
magnesium ion binding
glycoprotein binding
protein kinase activity
protein serine/threonine kinase activity
ATP binding
peptide binding
phosphoprotein binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
