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Invitrogen
CK1 alpha Recombinant Rabbit Monoclonal Antibody (25GB125)
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CK1 alpha Antibody (MA570429) in ICC/IF
Immunocytochemistry analysis of CK1 alpha in Hela cells. Sample was incubated with CK1 alpha monoclonal antibody (Product # MA570429) at a dilution of 1:1,000. Nuclei were stained blue with DAPI and Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
产品信息
MA570429
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
25GB125
抗原
A synthesized peptide derived from human Casein Kinase 1 alpha. The antigenic range is proprietary.
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Dry ice (international)
靶标信息
CNSK1A1 (CK1 alpha 1) is a member of the casein kinase I (CKI) gene family, which encodes serine/threonine kinases that preferentially phosphorylate acidic substrates. CKI proteins are monomeric, ranging from 25 to 55 kD, and are found in the nuclei, cytoplasm, and membrane fractions of eukaryotic cells. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: casein kinase 1, alpha 1; Casein kinase I isoform alpha; casein kinase I-alpha; CK I alpha; CK-I alpha; CK1; CKI alpha; CKI-alpha; clock regulator kinase; CSNK1A1/CK1; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; OTTHUMP00000224000; OTTHUMP00000224001; OTTHUMP00000224003; YIL035C
基因别名: 2610208K14Rik; 4632404G05Rik; 5430427P18Rik; CK1; CK1a; CKIa; Csnk1a; CSNK1A1; HEL-S-77p; HLCDGP1; PRO2975
UniProt ID: (Human) P48729, (Rat) P97633
Entrez Gene ID: (Human) 1452, (Rat) 113927, (Mouse) 93687
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
magnesium ion binding
glycoprotein binding
peptide binding
phosphoprotein binding
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
phagocytosis
Golgi organization
mitotic nuclear division
signal transduction
cell surface receptor signaling pathway
regulation of cell shape
Wnt signaling pathway
peptidyl-serine phosphorylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
intermediate filament cytoskeleton organization
cell division
negative regulation of canonical Wnt signaling pathway
regulation of GTP binding
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
cell morphogenesis
cell cycle
phosphorylation
