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CK2 alpha-1 Antibody (712564) in ICC/IF
Knockdown of CK2 alpha was achieved by transfecting HT-29 cells with specific siRNA (Silencer® select Product # s3638). Immunofluorescence analysis was performed on HT-29 cells (untransfected, panel a-d), transfected with CK2 alpha specific siRNA (panel i-l) or non-specific scrambled siRNA (panels e-h). Cells were fixed, permeabilized, and labeled with Anti-CK2 alpha Recombinant Rabbit Superclonal™ Antibody... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
712564
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
17HCLC
抗原
Protein corresponding to human CK2 alpha [aa1-aa335]
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Bovine, Cat, Sheep.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
靶标信息
CSNK2A1 is a serine/threonine protein kinase that phosphorylates acidic proteins. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by CK2 alpha-1 represents the alpha subunit. While CK2 alpha-1 is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for CK2 alpha-1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: casein kinase 2 alpha; casein kinase 2, alpha 1 polypeptide; casein kinase II alpha 1 polypeptide pseudogene; casein kinase II alpha 1 subunit; CK2 catalytic subunit alpha; protein kinase CK2; protein kinase; CK2 alpha''; unnamed protein product
基因别名: CK2A1; Cka1; Cka2; CKII; OCNDS
UniProt ID: (Human) P68400
Entrez Gene ID: (Human) 1457
double-strand break repair
protein folding
cellular response to DNA damage stimulus
signal transduction
positive regulation of cell proliferation
negative regulation of translation
peptidyl-serine phosphorylation
positive regulation of Wnt signaling pathway
positive regulation of cell growth
heterochromatin assembly
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of protein catabolic process
positive regulation of protein catabolic process
positive regulation of transcription, DNA-templated
protein stabilization
regulation of cell cycle
symbiont-mediated disruption of host cell PML body
negative regulation of signal transduction by p53 class mediator
positive regulation of aggrephagy
regulation of chromosome separation
negative regulation of double-strand break repair via homologous recombination
negative regulation of apoptotic signaling pathway
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