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Proteintech
TLE1 Monoclonal Antibody (2F2H11), CoraLite® Plus 488
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产品信息
CL488-66216
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
2F2H11
抗原
TLE1 fusion protein Ag21327
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: DPPPHMRVPT IPPNLAGIPG GKPAYSFHVT ADGQMQPVPF PPDALIGPGI PRHARQINTL NHGEVVCAVT ISNPTRHVYT GGKGCVKVWD ISHPGNKSPV SQLDCLNRDN YIRSCKLLPD GCTLIVGGEA STLSIWDLAA PTPRIKAELT SSAPACYALA ISPDSKVCFS CCSDGNIAVW DLHNQTLVRQ FQGHTDGASC IDISNDGTKL WTGGLDNTVR SWDLREGRQL QQHDFTSQIF SLGYCPTGEW LAVGMESSNV EVLHVNKPDK YQLHLHESCV LSLKFAYCGK WFVSTGKDNL LNAWRTPYGA SIFQSKESSS VLSCDISVDD KYIVTGSGDK KATVYEVIY
靶标信息
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1; RP11-203D19.1; TLE 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transducin-like enhancer protein 1
基因别名: ESG; ESG1; GRG1; TLE1
UniProt ID: (Human) Q04724
Entrez Gene ID: (Human) 7088
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
signal transduction
multicellular organism development
organ morphogenesis
positive regulation of gene expression
Wnt signaling pathway
negative regulation of Wnt signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of transcription, DNA-templated
beta-catenin-TCF complex assembly
negative regulation of anoikis
