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Proteintech
MAP2K4 Monoclonal Antibody (2E4C1), CoraLite® Plus 488
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产品信息
CL488-67333
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
2E4C1
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: NPPFKSTARF TLNPNPTGVQ NPHIERLRTH SIESSGKLKI SPEQHWDFTA EDLKDLGEIG RGAYGSVNKM VHKPSGQIMA VKRIRSTVDE KEQKQLLMDL DVVMRSSDCP YIVQFYGALF REGDCWICME LMSTSFDKFY KYVYSVLDDV IPEEILGKIT LATVKALNHL KENLKIIHRD IKPSNILLDR SGNIKLCDFG ISGQLVDSIA KTRDAGCRPY MAPERIDPSA SRQGYDVRSD VWSLGITLYE LATGRFPYPK WNSVFDQLTQ VVKGDPPQLS NSEEREFSPS FINFVNLCLT KDESKRPKYK ELLKHPFILM YEERAVEVAC YVCKILDQMP ATPSSPMYVD
靶标信息
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-Jun N-terminal kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 4; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; MAP kinase kinase 4; MAPK/ERK kinase 4; MAPKK 4; MEK 4; SAPK kinase 1; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1
基因别名: JNKK; JNKK1; MAP2K4; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1
UniProt ID: (Human) P45985
Entrez Gene ID: (Human) 6416
